Simplifying HIV Treatment Safely and Effectively – Dr. Simone Bonafé
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Simplification in HIV treatment refers to the strategy of modifying a patient's treatment regimen to make it easier to follow while maintaining the same virological efficacy and clinical safety. This approach may include:
- Reducing the number of pills per day – for example, switching from a combination of medications in multiple pills to a fixed-dose combination formulation (a single pill daily).
- Reducing the number of daily doses – concentrating therapy into a single dose per day, preferably on an empty stomach or with minimal food intake.
- Replacing medications with higher toxicity with safer alternatives, aiming to reduce long-term adverse effects (e.g., replacing first-generation tenofovir with tenofovir alafenamide).
- Use of long-acting injectable therapies, such as monthly or bimonthly intramuscular cabotegravir rilpivirine, in eligible patients.
Simplification is primarily indicated for patients with undetectable viral load and a good history of adherence, as it is a way to improve quality of life, reduce the risk of virological failures due to poor adherence, and minimize cumulative toxicities.
Dr. Simone Bonafé is an infectious disease physician with extensive experience in the care and treatment of patients living with HIV. Practicing in the city of Maringá for over a decade, she has built a career based on compassionate care, up-to-date scientific knowledge, and the pursuit of quality of life for her patients.
A specialist in the clinical management of HIV infection, Dr. Simone is recognized for her precise approach in choosing the most appropriate treatment regimens, considering the individual needs of each person. One of the cornerstones of her practice is treatment simplification, a strategy aimed at reducing the number of pills and adverse effects while maintaining effectiveness in viral control. This approach facilitates adherence to treatment and contributes to a full, healthy life with fewer impacts on patients' daily lives.
In her office, Dr. Simone offers individualized care, focusing on empathy, active listening, and absolute confidentiality, ensuring safety and trust throughout the entire care journey. In addition to HIV, she also provides care for other sexually transmitted infections, viral hepatitis, tuberculosis, and infections in immunocompromised patients.
If you are looking for guidance from an experienced, up-to-date professional committed to your health, schedule an appointment with Dr. Simone Bonafé.
Dr. Simone Bonafé Gianotto
Infectology - Maringá
CRM-PR 30714 - RQE 2695
Infectious disease physician certified by the Brazilian Society of Infectious Diseases.
PhD in infectious diseases from the Federal University of São Paulo (UNIFESP).
Professor in the Medicine course at the State University of Maringá (UEM).
Professor in the Medicine course at the University Center of Maringá (UNICESUMAR).
Medical Doctor Certified by Brazilian Society of Infectious Diseases.
Watch some interviews with Dr. Simone below: